Denis Noble CBE FRS FRCP (born 16 November 1936) is a British biologist who held the Burdon Sanderson Chair of Cardiovascular Physiology at Oxford University from 1984 to 2004 and was appointed Professor Emeritus and co-Director of Computational Physiology. He is one of the pioneers of Systems Biology and developed the first viable mathematical model of the working heart in 1960. His research focuses on using computer models of biological organs and organ systems to interpret function from the molecular level to the whole organism. Together with international collaborators, his team has used supercomputers to create the first virtual organ, the virtual heart.
As Secretary-General of the International Union of Physiological Sciences 1993-2001, he played a major role in launching the Physiome Project, an international project to use computer simulations to create the quantitative physiological models necessary to interpret the genome, and he was elected President of the IUPS at its world congress in Kyoto in 2009
He is also a philosopher of biology, and his book The Music of Life challenges the foundations of current biological sciences, questions the central dogma, its unidirectional view of information flow, and its imposition of a bottom-up methodology for research in the life sciencesContinue Reading »
